Correlation between Cmin and AUC
Median (range) measured Cmin concentrations were 1.3
(0.47-4.8) mg/L and 0.73 (0.28-2.4) mg/L for tezacaftor and ivacaftor,
respectively. A linear correlation was seen (figure 4) between observed
Cmin and the calculated AUC0-24h and
AUC0-12h, with Pearson’s r correlation
coefficients of 0.931 and 0.942 for tezacaftor and ivacaftor,
respectively. The variance of AUC could for 87% and 89% be explained
by Cmin for tezacaftor and ivacaftor determined by
R2, respectively.