AUC, Cmax, and elimination half-life of
tezacaftor-ivacaftor real-world compared to reported values
AUC0-24h for tezacaftor(-M1) and
AUC0-12h for ivacaftor(-M1 and –M6),
Cmax, and terminal elimination half-life
(t1/2,β) were assessed during every occasion by
Bayesian analysis. The obtained values were compared to their reported
values as described in the product information. (3)