Figure 1 – Schematic illustration of the pharmacokinetic model of tezacaftor and its main metabolite tezacaftor-M1. Abbreviations: D1; zero-order absorption into the gut compartment, KA; absorption rate constant, Vc TEZ/F; apparent tezacaftor central volume of distribution, Vp TEZ/F; apparent tezacaftor peripheral volume of distribution, Q/F; apparent intercompartmental clearance, CLTEZ/F; apparent tezacaftor clearance, Vc M1/(F*fm); apparent tezacaftor-M1 central volume of distribution of the fraction metabolized, Vp M1/(F*fm); apparent tezacaftor-M1 peripheral volume of distribution of the fraction metabolized, CLM1/(F*fm); apparent tezacaftor-M1 clearance of the fraction metabolized, Qm/fm; intercompartmental clearance of the fraction metabolized.