As there was a wide range in body weight (BW), allometric scaling for BW was applied on CL/F(*fm), Q/F(*fm) and V/F(*fm) (Eq. 1 and 2). Where θ is the typical estimate for CL, Q, Vc and Vp, normalized for a body weight of 70 kg.
Equation 1\(\frac{\text{CL}/Q}{F(*f_{m})}=\ \theta_{\text{CL}/Q}*\left(\frac{\text{BW}}{70}\right)^{0.75}\)
Equation 2\(\frac{V}{F(*f_{m})}=\ \theta_{V}*\left(\frac{\text{BW}}{70}\right)^{1\ }\)
IIV was assessed on CL (Eq. 3). Where ηCL is a normally distributed random variable with a mean of zero and an estimated variance of ω2, indicating the IIV in CL.
Equation 3 \(\text{CL}=\ \theta_{\text{CL}}*e^{\eta_{\text{CL}}}\)