Correlation between Cmin and AUC
In order to evaluate the correlation between Cmin and AUC, the measured Cmin for tezacaftor (>20h after dose) and ivacaftor (>10h after dose) were compared with the estimated AUC0-24h and AUC0-12h, respectively. Pearson’s r was used to evaluate the correlation between Cmin and AUC.