3. Strategies against A. baumannii persister cells
Two main approaches can be used to fight against persister cells: i) the prevention approach that uses antibacterial compounds that do not form persister cells. In this approach, the use of antibacterial agents’ combination is very useful. ii) the development of direct killing agents that do not generate persister cells itself or that are able to kill persister specifically. In this approach, the most effective strategy for eliminating persister cells is to take growth arrest into account and find a target not linked to multiplication activity [128]. Most effective anti-persister agents take often the bacterial membrane as a primary target. In A. baumannii , combination of treatments strategies and direct killing have been explored and will be presented in this section [128], [129].