3. Strategies against A. baumannii persister cells
Two main approaches can be used to fight against persister cells: i) the
prevention approach that uses antibacterial compounds that do not form
persister cells. In this approach, the use of antibacterial agents’
combination is very useful. ii) the development of direct killing agents
that do not generate persister cells itself or that are able to kill
persister specifically. In this approach, the most effective strategy
for eliminating persister cells is to take growth arrest into account
and find a target not linked to multiplication activity [128]. Most
effective anti-persister agents take often the bacterial membrane as a
primary target. In A. baumannii , combination of treatments
strategies and direct killing have been explored and will be presented
in this section [128], [129].