Recurrent preschool wheeze and role of Eosinophils
Eosinophils are increased number in established severe recurrent wheeze
by 3 years of age and this notable in the submucosa, while there is
increase in urinary eosinophil activation markers during acute wheeze
episodes.
In the INFANT Study, the RCT study Individualized Therapy for Asthma in
Toddlers, daily ICS vs daily LTRA vs intermittent ICS were given to 300
children aged 12–59 months old. Children who had aeroallergen
sensitization and/or blood eosinophils >300 cells/µl had the
greatest reduction in asthma symptoms in children receiving daily
ICS.2