Recurrent preschool wheeze and role of Eosinophils
Eosinophils are increased number in established severe recurrent wheeze by 3 years of age and this notable in the submucosa, while there is increase in urinary eosinophil activation markers during acute wheeze episodes.
In the INFANT Study, the RCT study Individualized Therapy for Asthma in Toddlers, daily ICS vs daily LTRA vs intermittent ICS were given to 300 children aged 12–59 months old. Children who had aeroallergen sensitization and/or blood eosinophils >300 cells/µl had the greatest reduction in asthma symptoms in children receiving daily ICS.2