Multi-Physics Modeling of Doxorubicin Binding to Ion-Exchange Resin in
Blood Filtration Devices
Abstract
A group of drugs used in Intra-Arterial Chemotherapy (IAC) have
intrinsic ionic properties, which can be used for filtering excessive
drugs from blood in order to reduce systemic toxicity. The ion-exchange
mechanism is utilized in an endovascular Chemofilter device which can be
deployed during the IAC for capturing ionic drugs after they have had
their effect on the tumor. In this study, the concentrated solution
theory is used to account for the effect of electrochemical forces on
the drug transport and adsorption by introducing an effective diffusion
coefficient in the advection-diffusion-reaction equation. Consequently,
a multi-physics model coupling hemodynamic and electrochemical forces is
developed and applied to simulations of the transport and binding of
Doxorubicin in the Chemofilter device. A comparison of drug adsorption
predicted by the computations to that measured in animal studies
demonstrated the benefits of using concentrated solution theory over the
Nernst-Plank relations for modeling drug binding.