Abstract
Background: Echocardiography derived myocardial performance may be
impaired.Objectives: To evaluate cardiac involvement including cardiac
biomarkers, echocardiographic findings in patients with COVID-19 and to
explore the effect of cardiac impairment on short-term outcome.Methods:
This study cohort was conducted from February 9, 2020, to March 28,
2020, in a single center at Wuhan Leishenshan Hospital. 213 patients
whose echocardiography were included. Demographic data, laboratory
results, echocardiographic findings were analyzed. Results:Among 213
patients confirmed with COVID-19,150 non-critical patients and 35
critical patients were discharged. 28 critical patients needed invasive
mechanical ventilation, 16 of whom died during the hospitalization, and
another 12 patients were transferred for continued treatment with
tracheotomy. The incidence of cardiovascular complications including
acute myocardial injury, arrhythmia and acute myocardial infarction was
higher in critical group . A total of 108 patients had abnormities on
echocardiography. 26(12.2%) patients have presented the signs of
pulmonary hypertension and the presence of pulmonary hypertension in
critical group was higher than that in non-critical group The cardiac
biomarkers at admission in critical patients were significantly higher
compared with non-critical patients.Multivariate analysis showed
high-sensitivity cardiac troponin I elevation and echocardiographic
signs of pulmonary hypertension ere independent risk factors of adverse
outcome.CONCLUSIONS: The elevation of cardiac markers and
echocardiographic signs of pulmonary hypertension are risk factors of
adverse outcome in patients with COVID-19. It’s meaningful to combine
echocardiography with cardiac markers to evaluate the prognosis of
patients with COVID-19.