Association between gestational diabetes mellitus and allergic diseases
in children
Abstract
Background: Existing knowledge suggests that gestational diabetes
mellitus was inconsistently associated with children allergic diseases.
The aim of this study was to identify the association between
gestational diabetes mellitus (GDM) and the risk of children allergic
diseases by systematic review. Methods: We searched and retrieved three
databases (PubMed, Web of Science and Cochrane Library) for articles on
the association between GDM and children allergic diseases published
before December 31, 2019. Stata software version 16.0 was used for
statistical analysis. Results: Eight published studies were included in
this meta-analysis. The pooled effect estimates showed the association
between GDM and allergic outcomes, including asthma
(OR:1.13,95%CI:1.01-1.27), wheezing (OR:1.12,95%CI:1.08-1.16), and
atopic dermatitis (OR:1.41,95%CI:1.31-1.53). GDM was not associated
with the risk of allergic sensitization, with a pooled effect estimate
of 1.45 (95%CI: 0.40, 5.23). Conclusion: GDM may increase the risk of
allergic diseases in children. However, this finding should be validated
with future large-sample epidemiological studies covering a wider
spectrum of allergic diseases.