Case report: Unusual Interaction Between Voriconazole and
Ritonavir/Lopinavir in a COVID-19 Patient Due to CYP2C19 Gene
Polymorphism
Abstract
Drug–drug interactions may be a serious issue for COVID-19-infected
patients needed kinds of conminant medications. voriconazole and
lopinavir/ritonavir were involved in interaction with cytochrome P450
enzymes, Therefore, coadministration of voriconazole and
lopinavir/ritonavir is estimated to interfere the effect of
voriconazole. However, the gene polymorphisms make these interactions
more complicating.