Late outcome after surgical and topical treatment for Aspergillus
mediastinitis after heart transplantation
- Paul Vogt,
- Raed Aser,
- Daniel Schmidlin,
- Paul Mohacsi,
- Pascal Berdat,
- Philip Went,
- Markus Flepp,
- Carlos Mestres
Abstract
Here we report the seven-year long-term survival after Aspergillus
fumigatus mediastinitis after heart transplantation, an uncommonly
described condition. A 66-year-old male developed infection with A.
fumigatus covering the entire thoracic cavity with a fungal turf after
orthotopic heart transplantation. Repeated surgical removal of
infectious and necrotic tissue together with innovative topical
treatment using voriconazole and chlorhexidine combined with systemic
antifungal treatment lead to control of infection. Definitive wound
closure was achieved by standard sternal refixation and latissimus dorsi
muscle flap plasty. Survival after A. fumigatus mediastinitis after
heart transplantation was achieved with sequential debridement in
combination with topical application of antifungal agents.27 Oct 2020Submitted to Journal of Cardiac Surgery 29 Oct 2020Submission Checks Completed
29 Oct 2020Assigned to Editor
03 Nov 2020Reviewer(s) Assigned
23 Nov 2020Review(s) Completed, Editorial Evaluation Pending
09 Dec 2020Editorial Decision: Revise Major
04 Jan 20211st Revision Received
05 Jan 2021Submission Checks Completed
05 Jan 2021Assigned to Editor
15 Jan 2021Reviewer(s) Assigned
18 Jan 2021Review(s) Completed, Editorial Evaluation Pending
09 Feb 2021Editorial Decision: Accept
Jul 2021Published in Journal of Cardiac Surgery volume 36 issue 7 on pages 2558-2561. 10.1111/jocs.15544