Thiol -- Disulphide Homeostasis as a Novel Oxidative Stress Marker in
Lung Tuberculosis Patient
Abstract
ABSTRACT Aims of Study: To compare dynamic thiol/disulfide homeostasis
between patients with with lung tuberculosis and healthy controls.
Methods: Our study included 50 patients with active lung tuberculosis
and 50 healthy controls. Serum thiol/disulfide was measured with a new
automated spectrometric method developed by Erel and Neselioglu, and
results were compared statistically. Results: We found that native and
total thiol levels were significantly decreased in patients with lung
tuberculosis, disulfide/native thiol and disulfide/total thiol levels
were found to be higher in lung tuberculosis patients when compared with
the control group. However, disulfide levels were higher in the control
group than in the patient group. Conclusions: Based on the results of
this study, it can be said that oxidative stress is closely associated
with lung tuberculosis pathogenesis. There is a need for new studies
that will show the possible effects of oxidative stress on lung
tuberculosis pathogenesis.