Prognostic value of intraductal carcinoma for adjuvant radiotherapy
candidates after radical prostatectomy
Abstract
ABSTRACT Objective: We aimed to investigate the prognostic significance
of intraductal carcinoma in radical prostatectomy (RP) specimens and
predictive value of IDC-P for biochemical recurrence and adjuvant
therapy decision. Method: Patients who underwent RP between 2000-2014
with final pathological stage pT3a and negative surgical margins (Group
1, n=35) and pT2 with positive surgical margins (Group 2, n=32) were
included. RP specimens were re-evaluated for the presence of IDC-P
component and other prognostic factors. In both groups, prognostic
factors were compared according to the presence of IDC-P and biochemical
recurrence status. Results: In group 1, IDC-P was detected in 5 cases
and biochemical recurrence was detected in 3 cases. Patients with IDC-P
showed significantly higher biochemical recurrence than those without
IDC-P (p=0.002). In univariate analysis, IDC-P was found to be
significantly associated with worse progression free survival
(p<0.001). In group 2, IDC-P was detected in 4 cases and
biochemical recurrence was detected in 10 cases. Also, tumor volume was
significantly higher in patients with IDC-P than those without IDC-P
(p=0.02). IDC-P was also significantly associated with worse progression
free survival in group 2 (p=0.033). Conclusions: In both groups, IDC-P
is a prognostic factor for progression free survival and / or
biochemical recurrence. Especially in these patients, presence of IDC-P
might be helpful for postoperative adjuvant therapy management decision.
Keywords: radical prostatectomy, intraductal carcinoma of prostate
(IDC-P), prostate cancer, biochemical recurrence, progression free
survival.