Effectiveness of ozone therapy in addition to conventional treatment on
mortality in patients with COVID-19
Abstract
Aim In this study, we aimed to investigate the effectiveness of ozone
therapy, which is one of the integrative medicine applications that has
been used safely for many years, on the prevalence of mortality in
patients receiving COVID-19 treatment. Methods This was a prospective,
controlled study conducted on patients with COVID-19 who were
hospitalized in Health Sciences University, Haydarpasa Numune Training
and Research Hospital. In this study, 55 patients were included. The
patients were divided into two groups as the ozone group and the control
group. Ozone therapy (major autohemotherapy) was applied to 37 patients
who were being treated with the appropriate COVID-19 treatment protocol
determined by the infectious diseases committee of our hospital. The
ozone treatment protocol consisted of seven sessions (1 session/day) of
intravenous ozone administration, applied in a volume of 100 mL and a
concentration of 30 μg/mL. Only the conventional COVID-19 treatment
protocol was applied to 18 patients in the control group. Clinical
follow-up was performed until the discharge of the patients from the
hospital with successful treatment or until the mortality occurred.
Factors affecting mortality were analyzed using univariate regression
analysis. Results Intensive care unit (ICU) hospitalization was required
in six of 37 patients who were treated with ozone (16.2%), while four
of 18 patients in the control group required ICU treatment (22.2%) (p =
0.713). When the mortality rates between the two groups were compared,
mortality was lower in the ozone group (p = 0.032). As a result of
univariate logistic regression analysis performed to determine the
factors affecting mortality, treatment without ozone therapy was
determined as a risk factor for mortality (OR:0.149, 95%CI 0.026-0.863,
p=0.034). Conclusion In this study, we demonstrated that administration
of ozone therapy along with the conventional medical treatment in
patients hospitalized for COVID-19 could reduce mortality.