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Efficacy of lorlatinib treatment in ALK-rearrangement lung cancer with severe symptomatic central nervous system metastases and poor performance status
  • Tomoyo Taketa,
  • Takahito Nakamura
Tomoyo Taketa
Hoshigaoka Iryo Center

Corresponding Author:[email protected]

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Takahito Nakamura
Hoshigaoka Iryo Center
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Abstract

Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) designed to penetrate the blood brain barrier. We report 2 cases of patients with ALK-rearrangement non-small cell carcinoma associated with severe symptomatic CNS metastases and poor performance status. Treatment with lorlatinib improved their neurological condition and performance status.

Peer review status:ACCEPTED

06 Dec 2020Submitted to Clinical Case Reports
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08 Dec 2020Submission Checks Completed
08 Dec 2020Assigned to Editor
29 Dec 2020Reviewer(s) Assigned
24 Jan 2021Review(s) Completed, Editorial Evaluation Pending
29 Jan 2021Editorial Decision: Accept