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Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype
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  • Min Jee Park,
  • So-Yeon Lee,
  • Si Hyeon Lee,
  • Mi-Jin Kang,
  • Kun Baek Song,
  • Sungsu Jung,
  • Ji-Sun Yoon,
  • Dong In Suh,
  • Youn Ho Shin,
  • Kyung Won Kim,
  • Kangmo Ahn,
  • Soo-Jong Hong
Min Jee Park
Asan Medical Center

Corresponding Author:[email protected]

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So-Yeon Lee
Asan Medical Center
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Si Hyeon Lee
University of Ulsan College of Medicine
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Mi-Jin Kang
Asan Institute for Life Sciences
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Kun Baek Song
Asan Medical Center
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Sungsu Jung
Yangsan Busan Daehakgyo Byeongwon
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Ji-Sun Yoon
MediplexSejong Hospital
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Dong In Suh
Seoul National University Children's Hospital
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Youn Ho Shin
CHA Gangnam Medical Center
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Kyung Won Kim
Yonsei University College of Medicine
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Kangmo Ahn
Sungkyunkwan University School of Medicine at Samsung Medical Center Cancer Center
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Soo-Jong Hong
Asan Medical Center
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Abstract

Background: Although atopic dermatitis (AD) is associated with certain gene variants, the rapidly increasing incidence of AD suggests that environmental factors contribute to disease development. In this study, we investigated the association of AD incidence and phenotype with antibiotic exposure within 6 months of age, considering the dose administered and genetic risk. Methods: This study included 1,637 children from the COCOA birth cohort. Pediatric allergists assessed the presence of AD at each visit and obtained information about antibiotic exposure for more than 3 days. IL-13 (rs20541) polymorphism was genotyped by the TaqMan method. We stratified the AD phenotypes into 4 groups and used multinomial logistic regression models for analysis. Results: Antibiotic exposure within 6 months of age was found to increase the risk of AD within 3 years of life (aOR=1.40, 95%, CI 1.09–1.81) in dose-dependent manner. Antibiotic exposure more than twice increased the risk of the early-persistent AD phenotype (aOR=2.50, 95% CI 1.35–4.63). There was a weak interaction between genetic polymorphisms and environmental factors on the development of AD (p for interaction=0.06). Children with the IL-13 (rs20541) GA+ AA genotype have a higher risk of the early-persistent AD phenotype when exposed to antibiotics more than twice than those with the IL-13 (rs20541) GG genotype and without exposure to antibiotics (aOR=4.73, 2.01–11.14). Conclusion: Antibiotic exposure within 6 months was related to the incidence of early-persistent AD and a dose-dependent increase in the incidence of AD in childhood, whose effect was modified by the IL-13 (rs20541) genotype.
26 Dec 2020Submitted to Pediatric Allergy and Immunology
04 Jan 2021Reviewer(s) Assigned
19 Feb 2021Review(s) Completed, Editorial Evaluation Pending
23 Feb 2021Editorial Decision: Revise Major
28 Apr 20211st Revision Received
29 Apr 2021Review(s) Completed, Editorial Evaluation Pending
29 Apr 2021Reviewer(s) Assigned
30 Apr 2021Editorial Decision: Accept
Oct 2021Published in Pediatric Allergy and Immunology volume 32 issue 7 on pages 1445-1454. 10.1111/pai.13531