loading page

Richter’s Transformation as leptomeningeal infiltration in a Chronic Lymphocytic Leukemia patient receiving Venetoclax. Could blood-brain barrier be a disease “sanctuary” during Venetoclax treatment?
  • +8
  • Maria Dimou,
  • Aikaterini Bitsani,
  • Maria Roumelioti,
  • Aglaia Dimitrakopoulou,
  • Theodoros Iliakis,
  • Vasileios Pardalis,
  • Ioannis Grafakos,
  • Sotiria Kalyva,
  • Athanasios Markopoulos,
  • Marie-Christine Kyrtsonis,
  • Panayiotis Panayiotidis
Maria Dimou
Laiko General Hospital

Corresponding Author:[email protected]

Author Profile
Aikaterini Bitsani
Laiko General Hospital
Author Profile
Maria Roumelioti
Laiko General Hospital
Author Profile
Aglaia Dimitrakopoulou
Laiko General Hospital
Author Profile
Theodoros Iliakis
Laiko General Hospital
Author Profile
Vasileios Pardalis
Laiko General Hospital
Author Profile
Ioannis Grafakos
Laiko General Hospital
Author Profile
Sotiria Kalyva
Laiko General Hospital
Author Profile
Athanasios Markopoulos
Laiko General Hospital
Author Profile
Marie-Christine Kyrtsonis
Laiko General Hospital
Author Profile
Panayiotis Panayiotidis
Laiko General Hospital
Author Profile

Abstract

We present a unique Richter's transformation case in CNS with identical to CLL clonal origin in a patient treated with Venetoclax. With our case we make implications on whether Venetoclax penetrates the blood-brain barrier and we address the debating issue of the appropriate Venetoclax dose in case of drug-drug interactions.
09 Jan 2021Submitted to Clinical Case Reports
11 Jan 2021Submission Checks Completed
11 Jan 2021Assigned to Editor
26 Jan 2021Reviewer(s) Assigned
16 Feb 2021Review(s) Completed, Editorial Evaluation Pending
16 Feb 2021Editorial Decision: Accept