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Morphological Changes in Nasal Mucosa in Patients with Sarcoidosis.
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  • Pavlos Pavlidis,
  • Evangelia Fouka,
  • Georgios Katsilis,
  • Haralampos Gouveris,
  • Despoina Papakosta
Pavlos Pavlidis
General Hospital of Thessaloniki G Papanikolaou

Corresponding Author:[email protected]

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Evangelia Fouka
General Hospital of Thessaloniki G Papanikolaou Pulmonology Department NHS
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Georgios Katsilis
General Hospital of Thessaloniki G Papanikolaou
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Haralampos Gouveris
Johannes Gutenberg University Hospital Mainz
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Despoina Papakosta
General Hospital of Thessaloniki G Papanikolaou Pulmonology Department NHS
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Abstract

Objectives: The purpose of this study was the evaluation of any alterations in the microvascular network of the nasal mucosa in patients with pulmonary sarcoidosis and the investigation of potential correlations with olfactory acuity and serum levels of angiotensin-converting enzyme (sACE). Design: Patients’ nasal mucosa was examined with contact endoscopy (CE). A novel classification scheme for the microvascular pattern at the anterior septal mucosa (Little’s area) was introduced and implemented. Olfaction was tested using sniffin’sticks. Fifteen healthy subjects served as controls. Participants: 15 patients with pulmonary sarcoidosis and sinonasal symptoms. Main outcome measures: Microvascular pattern at the anterior septal mucosa (Little’s area). Olfaction tested using sniffin’sticks. Setting: Tertiary referral medical centre. Results: The nasal microvascular network was disrupted under CE in most (14/15) patients, while in one patient no microvascular net could be detected. Moreover, hyposmia was documented in four patients and complete anosmia in one patient. In healthy subjects, a very strong correlation between vascular pattern of the mucosa and olfactory test results was found (r=0.93). Conclusions: Contact endoscopy findings show promise and should be further tested, to evaluate their validity as a surrogate marker of mucosal nasal inflammation in sarcoidosis patients with sinonasal symptoms. Vascular patterns of nasal mucosa and olfaction seem to be strong correlated.
06 Mar 2021Submitted to Clinical Otolaryngology
11 Mar 2021Submission Checks Completed
11 Mar 2021Assigned to Editor
18 Mar 20211st Revision Received
23 Mar 2021Submission Checks Completed
23 Mar 2021Assigned to Editor
29 Mar 2021Reviewer(s) Assigned
24 Apr 2021Review(s) Completed, Editorial Evaluation Pending
24 Apr 2021Editorial Decision: Revise Major
08 May 20212nd Revision Received
11 May 2021Submission Checks Completed
11 May 2021Assigned to Editor
11 May 2021Reviewer(s) Assigned
06 Jun 2021Review(s) Completed, Editorial Evaluation Pending
13 Jun 2021Editorial Decision: Revise Major
18 Jun 20213rd Revision Received
21 Jun 2021Submission Checks Completed
21 Jun 2021Assigned to Editor
22 Jun 2021Reviewer(s) Assigned
02 Aug 2021Review(s) Completed, Editorial Evaluation Pending
08 Aug 2021Editorial Decision: Revise Minor
09 Aug 20214th Revision Received
12 Aug 2021Submission Checks Completed
12 Aug 2021Assigned to Editor
16 Aug 2021Reviewer(s) Assigned
31 Aug 2021Review(s) Completed, Editorial Evaluation Pending
05 Sep 2021Editorial Decision: Accept
Jan 2022Published in Clinical Otolaryngology volume 47 issue 1 on pages 212-217. 10.1111/coa.13865