Clinical trials in cardiac xenotransplantation: are we ready to handle
ethical issues?
- Leonardo Rufino Garcia,
- Flavio Brito,
- Marcello Felicio,
- Andre Garzesi,
- Marcia Tardivo,
- Bertha Polegato,
- Marcos Minicucci,
- Leonardo Zornoff
Leonardo Rufino Garcia
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Corresponding Author:[email protected]
Author ProfileFlavio Brito
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileMarcello Felicio
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileAndre Garzesi
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileMarcia Tardivo
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileBertha Polegato
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileMarcos Minicucci
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileLeonardo Zornoff
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
Author ProfileAbstract
Heart allotransplantation has become one of the methods of choice in the
treatment of severe heart failure. In the face of its difficulties, such
as the unmet balance between organ supply and demand, the use of
xenotransplantation might be an attractive option in the near future,
even more with the ongoing progress achieved regarding the avoidance of
hyperacute rejection and primary organ disfunction, maintenance of
xenograft function and control of xenograft growth. To make possible
this translational challenge, some points must be taken into account
indeed, and they are the equipoise of human benefit and animal
suffering, the risk of unknown infections, a well prepared informed
consent, ethical and religious beliefs, and the role of cardiac
xenotransplantation in a ventricular assistance device era.15 Apr 2021Submitted to Journal of Cardiac Surgery 16 Apr 2021Submission Checks Completed
16 Apr 2021Assigned to Editor
16 Apr 2021Reviewer(s) Assigned
04 May 2021Review(s) Completed, Editorial Evaluation Pending
04 May 2021Editorial Decision: Revise Major
24 May 20211st Revision Received
26 May 2021Submission Checks Completed
26 May 2021Assigned to Editor
26 May 2021Reviewer(s) Assigned
08 Jun 2021Review(s) Completed, Editorial Evaluation Pending
10 Jun 2021Editorial Decision: Accept