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A non-cytotoxic regimen of decitabine to treat refractory T-cell large granular lymphocytic leukemia
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  • Misam Zawit,
  • CARMELO GURNARI,
  • Simona Pagliuca,
  • Hassan Awada,
  • Jaroslaw Maciejewski,
  • Yogen Saunthararajah
Misam Zawit
Cleveland Clinic Foundation

Corresponding Author:[email protected]

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CARMELO GURNARI
University of Rome Tor Vergata
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Simona Pagliuca
Cleveland Clinic Foundation
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Hassan Awada
Cleveland Clinic Foundation
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Jaroslaw Maciejewski
Cleveland Clinic Foundation
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Yogen Saunthararajah
Cleveland Clinic Foundation
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Abstract

T-cell large granular lymphocytic leukemia (T-LGL) is a chronic malignancy characterized by clonal expansion of cytotoxic T-cells possibly complicated by cytopenias of one or more myeloid lineages. By describing a multiply-refractory T-LGL case, this report highlights the importance of molecular-targeted and non-cytotoxic therapies in the context of frail elderly patients.

Peer review status:ACCEPTED

05 May 2021Submitted to Clinical Case Reports
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06 May 2021Submission Checks Completed
06 May 2021Assigned to Editor
10 May 2021Reviewer(s) Assigned
15 May 2021Review(s) Completed, Editorial Evaluation Pending
03 Jun 2021Editorial Decision: Revise Minor
04 Jun 20211st Revision Received
05 Jun 2021Submission Checks Completed
05 Jun 2021Assigned to Editor
05 Jun 2021Review(s) Completed, Editorial Evaluation Pending
14 Jun 2021Editorial Decision: Accept