Impact of Nutritional Assessment on Long-Term Outcomes in Patients with
Carotid Artery Stenting
Abstract
Objective: Malnutrition is associated with poor clinical outcomes in
many diseases. The Controlling Nutritional Status (CONUT) is an
objective index used for evaluating nutritional status of hospitalized
patients. The aim of this study was to investigate the relationship
between malnutrition assessed by CONUT score and the prognosis in
patients undergoing carotid artery stenting (CAS). Methods: The study
included 170 patients who underwent CAS due to symptomatic or
asymptomatic severe carotid artery stenosis. Median follow-up period was
50 (interquartile range [IQR], 41-60) months. Patients were divided
into two groups according to the CONUT score: (i) normal nutrition
(<2) and (ii) malnutrition (≥2). Primary endpoint was accepted
as MACE (major adverse cardiac events) including all-cause death and
ischemic stroke. Results:The prevalence of MACE was significantly higher
in the malnutrition group (p=0.001). Kaplan Meier analysis showed lower
survival rates in the malnutrition group (log rank = 9.36, p=0.002;
Figure 4). In multivariate logistic regression analysis, age and CONUT
score were independent predictors of all-cause death and stroke after
adjustment for confounding factors, respectively, (OR: 1.058, 95% CI:
1.013-1.105, p=0.011, OR: 1.318, 95% CI: 1.017-1.881, p=0.039).
Conclusion: Higher CONUT scores were associated with adverse outcomes in
patients with CAS. Malnutrition assessed by the CONUT score may provide
valuable prognostic information in patients with CAS.