Current Approaches to Management of Bone Sarcoma in Adolescent and Young
Adult (AYA) Patients
Abstract
Bone tumors are a group of histologically diverse diseases which occur
across all ages. Two of the commonest, osteosarcoma (OS) and Ewing
sarcoma (ES), are regarded as characteristic AYA cancers with an
incidence peak in AYAs. They are curable for some but associated with
unacceptably high rates of treatment failure and morbidity. The
introduction of effective new therapeutics for bone sarcomas is slow,
and to date, complex biology has been insufficiently characterized to
allow more rapid therapeutic exploitation. This review focuses on
current standards of care, recent advances that have or may soon change
that standard of care and challenges to the expert clinical research
community that we suggest must be met.