Sequential allogenic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive Myeloid Sarcoma and Acute B-Lymphoblastic Leukemia

Giuliana Rizzuto; Matteo Leoncin; Silvia Imbergamo; Daniela Taurino; Maria Caterina Micò; Manuela Tosi; Anna Michelato; Ksenija  Buklijas; Orietta Spinelli; Federico Lussana; Federica Lessi; Marco Pizzi; Laura Bonaldi; Gianni Binotto; Alessandro Rambaldi; Carmela Gurrieri

doi:10.22541/au.162845166.67964426/v1

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Sequential allogenic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive Myeloid Sarcoma and Acute B-Lymphoblastic Leukemia

Giuliana Rizzuto,
Matteo Leoncin,
Silvia Imbergamo,
Daniela Taurino,
Maria Caterina Micò,
Manuela Tosi,
Anna Michelato,
Ksenija Buklijas,
Orietta Spinelli,
Federico Lussana,
Federica Lessi,
Marco Pizzi,
Laura Bonaldi,
Gianni Binotto,
Alessandro Rambaldi,
Carmela Gurrieri

Abstract

The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1-JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here we report an interesting case of PCM1-JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.

22 Jul 2021Submitted to Clinical Case Reports

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22 Jul 2021Submission Checks Completed

22 Jul 2021Assigned to Editor

08 Aug 2021Reviewer(s) Assigned

12 Sep 2021Review(s) Completed, Editorial Evaluation Pending

21 Sep 2021Editorial Decision: Revise Minor

09 Nov 20211st Revision Received

15 Nov 2021Submission Checks Completed

15 Nov 2021Assigned to Editor

15 Nov 2021Review(s) Completed, Editorial Evaluation Pending

01 Dec 2021Editorial Decision: Accept

Abstract

Peer review status:ACCEPTED