Identification of p.Met215Ile mutation of the MC4R gene in a Moroccan
woman with obesity
- Meriem El Fessikh
, - HAKIM BELGHITI,
- ZOUHAIR ELKARHAT,
- HASSANIA GUERINECH,
- Nadia DAKKA,
- Jamila El Baghdadi
HAKIM BELGHITI
Hopital Militaire d'Instruction Mohammed V
Author ProfileHASSANIA GUERINECH
Hopital Militaire d'Instruction Mohammed V
Author ProfileNadia DAKKA
Universite Mohammed V de Rabat Faculte des Sciences
Author ProfileJamila El Baghdadi
Hopital Militaire d'Instruction Mohammed V
Author ProfileAbstract
The MC4R is involved in the leptin-melanocortin pathway which mutations
can lead to severe forms of obesity. We report one rare mutation
p.Met215Ile in a woman with morbid obesity. This mutation leads to
changes in protein structure through the loss of hydrophobic
interactions and it is predicted to be disease-causing.09 Sep 2021Submitted to Clinical Case Reports 14 Sep 2021Submission Checks Completed
14 Sep 2021Assigned to Editor
20 Sep 2021Reviewer(s) Assigned
05 Oct 2021Review(s) Completed, Editorial Evaluation Pending
05 Oct 2021Editorial Decision: Revise Minor
18 Oct 20211st Revision Received
19 Oct 2021Submission Checks Completed
19 Oct 2021Assigned to Editor
19 Oct 2021Review(s) Completed, Editorial Evaluation Pending
26 Oct 2021Editorial Decision: Accept
