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Etiology and characteristics and of community-acquired pneumonia among children requiring bronchoalveolar lavage in North China
  • +10
  • Ruihan Liu,
  • Yuyan Zhang,
  • Wenli Han,
  • Lei Yang,
  • Na Li,
  • Yu Wang,
  • Xueyun Ren,
  • Meiyun Xin,
  • Tongshu Hou,
  • Fenghai Niu,
  • Yayan Wang,
  • Qing Zhao,
  • Jun Ning
Ruihan Liu
Jining Medical University

Corresponding Author:[email protected]

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Yuyan Zhang
Jining Medical University
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Wenli Han
Jining Medical University
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Lei Yang
Jining Medical University
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Na Li
Jining Medical University
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Yu Wang
Jining Medical University
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Xueyun Ren
Jining Medical University
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Meiyun Xin
Jining Medical University
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Tongshu Hou
Binzhou Medical University
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Fenghai Niu
Jining Medical University
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Yayan Wang
Jining Medical University
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Qing Zhao
Jining Medical University
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Jun Ning
Jining Medical University
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Abstract

Objective: To identify the pathogens and compare the clinical characteristics between different type pathogen infection among children with community-acquired pneumonia (CAP) requiring bronchoalveolar lavage. Study design: Children <14 years old hospitalized with CAP requiring bronchoalveolar lavage were enrolled between February 2019 to January 2020. Multiplex reverse transcription polymerase chain reaction (mRT-PCR) and loop-mediated isothermal amplification (LAMP) were used for pathogen detection. The demographic and clinical characteristics were compared between different type pathogen infection groups. Results: Among 1166 children studied, ≥1 pathogen was detected in 1084 (93.0%) children and co-infection was detected in 215 (18.4%) children. Mycoplasma pneumoniae, Streptococcus pneumoniae and adenovirus were the most frequently detected pathogens. Children infected with atypical bacteria alone were older and more likely to display a fever, cough, decreased breath sounds, consolidation, single lobar infiltration, mucosal erosion and/or necrosis and plastic bronchitis. Children with virus-atypical bacteria co-infection were more prone to manifest fatigue, chest pain, tachypnea, chest indrawing, and mucosal erosion and/or necrosis. Those infected with virus alone or co-infected with ≥3 pathogens were liable to display changes in bronchial morphology. Conclusions: Pathogens were detected in 93.0% of enrolled children. M. pneumoniae infection might be the greatest pediatric disease burden due to CAP in North China. Keywords: Children; community-acquired pneumonia; bronchoalveolar lavage fluid; etiology; co-infection.
08 Sep 2021Submitted to Pediatric Pulmonology
09 Sep 2021Submission Checks Completed
09 Sep 2021Assigned to Editor
21 Sep 2021Reviewer(s) Assigned
15 Oct 2021Review(s) Completed, Editorial Evaluation Pending
15 Oct 2021Editorial Decision: Revise Major