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Multi-objective Optimization, Process Scale-up Techno-Economics and Uncertainty analysis of Microwave-Assisted Extraction of Phenolic-Rich Extract from Allium sativum
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  • Olusola Oke,
  • Oladayo Adeyi,
  • Bernerd Okolo,
  • Samuel Okhale,
  • Chiamaka Ude,
  • John Adeyi,
  • John Otolorin,
  • Nnabodo Darlinton,
  • James Adeyanju,
  • adewale Adeniyi,
  • Kenechi Nwonsu-Obieogu,
  • Emmanuel Eleanyan
Olusola Oke
Michael Okpara University of Agriculture

Corresponding Author:[email protected]

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Oladayo Adeyi
Michael Okpara University of Agriculture
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Bernerd Okolo
Michael Okpara University of Agriculture
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Samuel Okhale
National institute of pharmaceutical research and development
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Chiamaka Ude
Michael Okpara University of Agriculture
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John Adeyi
Ladoke Akintola University of Technology
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John Otolorin
Michael Okpara University of Agriculture
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Nnabodo Darlinton
Michael Okpara University of Agriculture
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James Adeyanju
Ladoke Akintola University of Technology
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adewale Adeniyi
University of Ilorin
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Kenechi Nwonsu-Obieogu
Michael Okpara University of Agriculture
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Emmanuel Eleanyan
Michael Okpara University of Agriculture
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Abstract

Allium sativum extract is one of the medicinal and aromatic products used in pharmaceutical and food industries. The scientific literature bibliography regarding process scale-up simulation and techno-economics of phenolic extract from Allium sativum microwave-assisted extraction is seldom reported. This study presented optimization and techno-economic evaluation of phenolics recovery from allium sativum microwave-assisted extraction. Box-benken design extraction experiment was conducted at irradiation power (520 – 1040 W), extraction time (2- 10 minutes) and solid-liquid ratio (0.4 – 1 g/100 ml). The extraction conditions that optimized experimental extractible yield and Total Phenolic Content (TPC) were evaluated in Box-benken desirability of Response Surface Methodology. Bioactive finger printing of the extract was analyzed using HPLC. Aspen Batch Process Developer was used for the process techno-economic analysis. Profitability uncertainty was analyzed using Monte-Carlo Simulation (MCS). Optimal extractible yield (28.62 %) and TPC (76.8 mgGAE/g dry extract) were obtained at irradiation time 7.62 mins, microwave power 826.67 Watt with solid-liquid ratio 0.55g/100ml. The HPLC fingerprint revealed Bentulinic acid, galic acid, chlorogenic acid, ellagic acid and ferulic acid. Cost of Manufacturing (COM) for 5L, 50L and 500L extractors gave US$ 1480, US$ 220 and US$ 56 respectively. Techno-economic results of 500L extraction capacity with 900 kg/year design gave batch size (0.25 kg), production rate (2 kg/mins), cycle time (125 mins), discounted NPV (38133 US$), ROI (34%), IRR (37%) and PBT (2.94yrs). MCS results show 85.58 % and 83.53certainties of achieving base case ROI PBT. Therefore, the study shows that MAE of garlic powder is economically feasible.
12 Nov 2021Submitted to Engineering Reports
15 Nov 2021Submission Checks Completed
15 Nov 2021Assigned to Editor
18 Jan 2022Reviewer(s) Assigned
02 Mar 2022Editorial Decision: Revise Major
08 May 20221st Revision Received