loading page

Telomere length positively correlates with pace-of-life in a sex- and cohort-specific way and elongates with age in a wild mammal
  • +3
  • Mathilde Tissier,
  • Patrick Bergeron,
  • Dany Garant,
  • Sandrine Zahn,
  • Francois Criscuolo,
  • Denis Réale
Mathilde Tissier
Bishop's University

Corresponding Author:[email protected]

Author Profile
Patrick Bergeron
Université de Sherbrooke
Author Profile
Dany Garant
Université de Sherbrooke
Author Profile
Sandrine Zahn
Centre National de la Recherche Scientifique
Author Profile
Francois Criscuolo
CNRS
Author Profile
Denis Réale
Université du Québec à Montréal
Author Profile

Abstract

Understanding ageing and the diversity of life histories is a cornerstone in biology. Telomeres, the protecting caps of chromosomes, are thought to be involved in ageing, cancer risks and to modulate life-history strategies. They shorten with cell division and age in somatic tissues of most species, possibly limiting lifespan. The resource allocation trade-off hypothesis predicts that short telomeres have thus co-evolved with early reproduction, proactive behaviour and reduced lifespan: a fast Pace-of-Life Syndrome (POLS). Conversely, since short telomeres may also reduce the risks of cancer, the anti-cancer hypothesis advances that they should be associated with slow POLS. Conclusion on which hypothesis best supports the role of telomeres as mediators of life-history strategies is hampered by a lack of study on wild short-lived vertebrates, apart from birds. Using seven years of data on wild Eastern chipmunks Tamias striatus, we highlighted that telomeres elongate with age and do not limit lifespan in this species. Furthermore, short telomeres correlated with a slow POLS in a sex-specific way. Females with short telomeres had a delayed age at first breeding and a lower fecundity rate than females with long telomeres, whereas those differences were not recorded in males. Our findings support most predictions adapted from the anti-cancer hypothesis, but none of those made under the resource allocation trade-off hypothesis. Results are in line with an increasing body of evidence suggesting that other evolutionary forces than resource allocation trade-offs shape the diversity of telomere length in adult somatic cells and the relationships between telomeres and life-histories.
30 Mar 2022Submitted to Molecular Ecology
01 Apr 2022Reviewer(s) Assigned
02 May 2022Review(s) Completed, Editorial Evaluation Pending
03 May 2022Editorial Decision: Revise Minor
03 May 2022Review(s) Completed, Editorial Evaluation Pending
03 May 20221st Revision Received
12 May 2022Editorial Decision: Accept
Jul 2022Published in Molecular Ecology volume 31 issue 14 on pages 3812-3826. 10.1111/mec.16533