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Physicochemical and biological properties of calcium phosphate/chondroitin sulfate bone cement containing tetracalcium phosphate nanorod powders
  • rahim jahandideh,
  • Aliasghar behnamghader,
  • Saeed Hesaraki
rahim jahandideh
Materials and Energy Research Center

Corresponding Author:[email protected]

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Aliasghar behnamghader
Materials and Energy Research Center
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Saeed Hesaraki
Materials and Energy Research Center
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Abstract

Tetracalcium phosphate (TTCP) is one of the main powder components in self-setting calcium phosphate cements for hard tissue applications. In this study, two types of calcium phosphate/chondroitin sulfate bone cements in which TTCP powders in nanoscale-rod like (R-TTCP) and micro-conventional irregular shape (C-TTCP) were used. The first one was synthesized by reverse microemulsion chemical process and the second one, was prepared by thermal conventional method. The results showed that both cements formed hydroxyapatite as the result of cementation process. The R-TTCP cement revealed a slightly longer initial but no difference in final setting time, less compressive strength, higher porosity and better degradation behavior compared to C-TTCP one. The both cements presented similar tendency to the formation of a dense hydroxyapatite on their outer surfaces through immersion in simulated body fluid. Taking into consideration the initial porosity, the cement made from R-TTCP rod like nanopowder presented more aptness to participate in ion exchange in SBF resulting to fill the 15% more initial porosity via the precipitation of hydroxyapatite mineral. From the biological point of view, analysis of cytotoxicity and MG63 osteoblastic-cell behavior proved that the both cements had good viability and proper cell adhesion and activity.
20 Jun 2022Submitted to Micro & Nano Letters
27 Jun 2022Submission Checks Completed
27 Jun 2022Assigned to Editor
02 Jul 2022Reviewer(s) Assigned
31 Jul 2022Review(s) Completed, Editorial Evaluation Pending
02 Aug 2022Editorial Decision: Revise Major
28 Aug 20221st Revision Received
31 Aug 2022Submission Checks Completed
31 Aug 2022Assigned to Editor
01 Sep 2022Reviewer(s) Assigned
02 Sep 2022Review(s) Completed, Editorial Evaluation Pending
09 Sep 2022Editorial Decision: Revise Minor
11 Sep 20222nd Revision Received
12 Sep 2022Submission Checks Completed
12 Sep 2022Assigned to Editor
15 Sep 2022Reviewer(s) Assigned
17 Sep 2022Review(s) Completed, Editorial Evaluation Pending
21 Sep 2022Editorial Decision: Accept