loading page

Association of Serum Anion Gap and Risk of Long-term Mortality in Patients Following Coronary Artery Bypass Grafting: A Propensity Score Matching Study
  • +15
  • Xiaochun Ma,
  • Diming Zhao,
  • Yi Li,
  • JunJie Huang,
  • Zheng Zheng,
  • Xiangxi Zhang,
  • Yilin Liu,
  • Huibo Ma,
  • Feng Ji,
  • Yan Yun,
  • Congshan Ji,
  • Zhenqiang Xu,
  • Xiaomei Yang,
  • Hechen Shen,
  • Shanghao Chen,
  • Shijie Zhang,
  • Haizhou Zhang,
  • Chengwei Zou
Xiaochun Ma
Shandong University Cheeloo College of Medicine

Corresponding Author:[email protected]

Author Profile
Diming Zhao
Shandong University Cheeloo College of Medicine
Author Profile
Yi Li
Shandong University Cheeloo College of Medicine
Author Profile
JunJie Huang
Shandong Provincial Hospital
Author Profile
Zheng Zheng
Shandong Provincial Hospital
Author Profile
Xiangxi Zhang
Shandong Provincial Hospital
Author Profile
Yilin Liu
Shandong Provincial Hospital
Author Profile
Huibo Ma
The Affiliated Hospital of Qingdao University
Author Profile
Feng Ji
Dongying City PPL’s Hospital Dongying 257000 Shandong China
Author Profile
Yan Yun
Qilu Hospital of Shandong University
Author Profile
Congshan Ji
Shandong Provincial Hospital
Author Profile
Zhenqiang Xu
Shandong Provincial Hospital
Author Profile
Xiaomei Yang
Shandong Provincial Hospital
Author Profile
Hechen Shen
Shandong University Cheeloo College of Medicine
Author Profile
Shanghao Chen
Shandong University Cheeloo College of Medicine
Author Profile
Shijie Zhang
Shandong University Cheeloo College of Medicine
Author Profile
Haizhou Zhang
Shandong University Cheeloo College of Medicine
Author Profile
Chengwei Zou
Shandong University Cheeloo College of Medicine
Author Profile

Abstract

Background: The present study aimed to explore the relationship between serum anion gap (AG) and long-term mortality in patients undergoing coronary artery bypass grafting (CABG). Methods: Clinical variables were extracted among patients undergoing CABG from Medical Information Mart for Intensive Care III (MIMIC III) database. The primary outcome was four-year mortality following CABG. An optimal cut-off value of AG was determined by receiver operating characteristic (ROC) curve. The Kaplan-Meier (K-M) analysis and multivariate Cox hazard analysis were performed to investigate the prognostic value of AG in long-term mortality after CABG. In order to eliminate the bias between different groups, propensity score matching (PSM) was conducted to validate the findings. Results: The optimal cut-off value of AG was 17.00 mmol/L. Then a total of 3,162 eligible patients enrolled in this study were divided into a high AG group (≥17.00, n=1,022) and a low AG group (<17.00, n=2,140). A lower survival rate was identified in the high AG group based on K-M curve (p<0.001). Compared with patients in the low AG group, patients in the high AG group had an increased risk of long-term mortality [One-year: HR 2.309, 95% CI (1.672-3.187), P<0.001; two-year: HR 1.813, 95% CI (1.401-2.346), P<0.001; three-year: HR 1.667, 95% CI (1.341-2.097), P<0.001; four-year: HR 1.710, 95% CI (1.401-2.087), P<0.001] according to multivariate Cox hazard analysis. And further validation of above results were consistent in the matched cohort after PSM. Conclusions: The AG is an independent predictive factor for long-term all-cause mortality in patients following CABG, where a high AG value is associated with an increased mortality.
29 Aug 2022Submitted to Journal of Cardiac Surgery
30 Aug 2022Submission Checks Completed
30 Aug 2022Assigned to Editor
31 Aug 2022Reviewer(s) Assigned
10 Oct 2022Review(s) Completed, Editorial Evaluation Pending
27 Oct 2022Editorial Decision: Accept