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Accelerated LVAD Pump Thrombosis in COVID-19 Patient: Case report and Mini review
  • +8
  • Ishaq Wadiwala J,
  • Pankaj Garg,
  • Mohammad Alomari,
  • Mohamed Elawady S,
  • Emad Alamouti-Fard,
  • Lekhya Raavi,
  • Nargis Mateen,
  • Fazal Khan,
  • Md Walid Akram Hussain,
  • Si Pham,
  • Samuel Jacob
Ishaq Wadiwala J
Mayo Clinic in Florida

Corresponding Author:[email protected]

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Pankaj Garg
Mayo Clinic in Florida
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Mohammad Alomari
Mayo Clinic in Florida
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Mohamed Elawady S
Mayo Clinic in Florida
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Emad Alamouti-Fard
Mayo Clinic in Florida
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Lekhya Raavi
Mayo Clinic in Florida
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Nargis Mateen
Mayo Clinic in Florida
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Fazal Khan
Mayo Clinic in Florida
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Md Walid Akram Hussain
Mayo Clinic in Florida
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Si Pham
Mayo Clinic in Florida
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Samuel Jacob
Mayo Clinic in Florida
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Abstract

Coronavirus (COVID-19) infection exposes patients with heart failure to a higher risk of morbidity and mortality. In LVAD patients, one of the key problems that can lead to life-threatening low-flow or pump malfunction due to thrombus development in the inflow cannula, device body, or outflow graft, implicating hemodynamic instability, hemolysis, renal or hepatic failure, or cerebral or peripheral thromboembolism. [Endothelial protein C receptor and thrombomodulin levels are elevated along with procoagulants such as factor VIII, P-selectin, and von Willebrand factor and downregulated along with thrombomodulin as a result of the cytokine storm released by endothelial and immune cells. In general ,](#ref-0013) LVAD thrombosis has been found to occur in 2–13% of adult patients who use current continuous-flow devices. However, LVAD thrombosis due to COVID-19 is underreported and a few cases presented. We present a case of accelerated LVAD outflow thrombosis in the setting of COVID-19 infection with multiorgan failure.
30 Sep 2022Submitted to Journal of Cardiac Surgery
30 Sep 2022Submission Checks Completed
30 Sep 2022Assigned to Editor
02 Oct 2022Reviewer(s) Assigned
08 Oct 2022Review(s) Completed, Editorial Evaluation Pending
08 Oct 2022Editorial Decision: Accept