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EFFECT OF THE POVIDONE IODINE, HYPERTONIC ALKALINE SOLUTION AND SALINE NASAL LAVAGE ON NASOPHARYNGEAL VIRAL LOAD IN COVID-19
  • +13
  • Aysegul Karaaltin,
  • ozgur yigit,
  • dogan cakan,
  • özer akgül,
  • Enes Yiğit,
  • yetkin zeki yılmaz,
  • Kays Burak Çakır,
  • gamze çiftçi,
  • Nihal Seden,
  • abdurrahman çağlıyan,
  • Efe Can,
  • özgür dikme,
  • yalçın hacıoğlu,
  • ilker inanç balkan,
  • özgün enver,
  • Ahmet Ozdogan
Aysegul Karaaltin
Istanbul University

Corresponding Author:[email protected]

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ozgur yigit
istanbul education and research hospital
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dogan cakan
Istanbul University-Cerrahpasa
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özer akgül
Istanbul Aydin Universitesi
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Enes Yiğit
Istanbul Teaching and Research Hospital
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yetkin zeki yılmaz
İstanbul Üniversitesi-Cerrahpaşa
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Kays Burak Çakır
Istanbul Universitesi-Cerrahpasa
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gamze çiftçi
İstanbul Üniversitesi-Cerrahpaşa
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Nihal Seden
Istanbul Teaching and Research Hospital
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abdurrahman çağlıyan
Istanbul Teaching and Research Hospital
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Efe Can
Istanbul Teaching and Research Hospital
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özgür dikme
Istanbul Education Research Hospital
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yalçın hacıoğlu
Istanbul Teaching and Research Hospital
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ilker inanç balkan
İstanbul Üniversitesi-Cerrahpaşa
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özgün enver
Istanbul Aydin Universitesi
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Ahmet Ozdogan
Istanbul University Cerrahpasa Medical Faculty
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Abstract

Objective: The causative virus of COVID-19 is SARS-CoV-2. The aim of the present study was to invastigate the in vivo virucidal activity of nasal irrigation with saline, nasal irrigation with Povidone-iodine (PVP-I) 1%, nasal irrigation with hypertonic alkaline and nasal irrigation with PVP-I 1% against SARS CoV- 2. Design: The present study was a prospective randomized clinical trial. Setting: A multicenter study involving tertiary care centers. Participants: The study included adult outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal swabs were positive. One hundred twenty patients divided into four equal groups. Standard COVID-19 treatment was given to group 1 (n=30), nasal irrigation containing isotonic solution was added to patients’ treatment in group 2 (n=30), nasal irrigation containing 1% PVP solution was added to patients’ treatment in group 3(n=30), and nasal irrigation containing 1% PVP solution and nasal irrigation containing hypertonic alkaline solution was added to patients’ treatment in group 4 (n=30). Main outcome measures: On the first day of diagnosis (day 0), nasopharyngeal swab samples were taken, on the 3rd and 5th days the nasopharyngeal viral load reduction in quantitative RT-PCR tests were calculated. Results: Between the 0-3rd Day and 0-5th days, the nasopharyngeal viral load reduction was significant in all groups (p< .05). In paired comparisons of groups, the nasopharyngeal viral load decrease in group 4 in first 3 days was significantly lower than all groups (p < .05). The nasopharyngeal viral load degrease in groups 3 and 4 in the first 5 days were significantly lower than group 1 (p < .05). Conclussion: This study was reveal that the use of hypertonic alkaline nasal irrigation together with 1% povidone-iodine was more effective in reducing viral load in the early period. The decreased nasopharyngeal viral load may reduce the carriage of infectious SARS-CoV-2 in patients. Our results suggest that 1% povidone-iodine and hypertonic alkaline nasal irrigation may be promising modality to prevent the COVID-19 epidemic.
25 Sep 2022Submitted to Clinical Otolaryngology
26 Oct 2022Submission Checks Completed
26 Oct 2022Assigned to Editor
02 Nov 2022Reviewer(s) Assigned
21 Nov 2022Review(s) Completed, Editorial Evaluation Pending
27 Nov 2022Editorial Decision: Revise Major
31 Dec 20221st Revision Received
10 Jan 2023Submission Checks Completed
10 Jan 2023Assigned to Editor
15 Jan 2023Reviewer(s) Assigned
31 Jan 2023Review(s) Completed, Editorial Evaluation Pending
12 Feb 2023Editorial Decision: Revise Minor
13 Feb 20232nd Revision Received
15 Feb 2023Submission Checks Completed
15 Feb 2023Assigned to Editor
17 Feb 2023Reviewer(s) Assigned
27 Feb 2023Review(s) Completed, Editorial Evaluation Pending
12 Mar 2023Editorial Decision: Accept