Impact of Vitamin D Supplementation on Covid-19 Vaccine Response and IgG
Antibodies in Deficient Women: A randomized controlled trial
Abstract
Background: The immune response of COVID-19-vaccinated women
with vitamin D deficiency was investigated by giving vitamin D
supplementation. Methods: The study consisted of young
volunteer women who completed two doses of COVID-19 vaccines and spent
an average of more than 65 days. Participants in the D group (n=14
Pfizer-BioNTech, 2 Sinovac) were given 150,000 IU vitamin D supplements,
and no supplement was given to the C group (n=14 Pfizer-BioNTech, 3
Sinovac). Results: When the last measurements were examined
(W3) after vitamin D supplementation, it was observed that serum 25(OH)
D levels regularly increased (p=0.001). It was observed that the W1
measurement of the D group was lower than those of the C group
(P<0.001), and there was a significantly higher increase in
the W2 measure (P<0.001). In addition, although there was no
correlation between serum IgG and 25(OH) D in the D group at the
beginning, a significant positive correlation was found in the final
measurement (r=0.558, p=0.031). Conclusion: It was observed
that the use of vitamin D significantly increased serum IgG levels
compared to those who did not use vitamin D, depending on the duration,
and in the long term, it was observed that it remained above the
baseline. It has been determined that there is a positive and
significant correlation between the last measurement of serum IgG and
25(OH) vitamin D levels during the use of vitamin D.