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NLRP2 in health and disease
  • +4
  • Tongtong Zhang,
  • Fei Xing,
  • Mingcui Qu,
  • Zhihu Yang,
  • Yafei Liu,
  • Yongchao Yao,
  • Na Xing
Tongtong Zhang
The First Affiliated Hospital of Zhengzhou University
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Fei Xing
The First Affiliated Hospital of Zhengzhou University
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Mingcui Qu
The First Affiliated Hospital of Zhengzhou University
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Zhihu Yang
The First Affiliated Hospital of Zhengzhou University
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Yafei Liu
The First Affiliated Hospital of Zhengzhou University
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Yongchao Yao
The First Affiliated Hospital of Zhengzhou University
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Na Xing
The First Affiliated Hospital of Zhengzhou University

Corresponding Author:[email protected]

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Abstract

NLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its specific  functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproductive system is unclear. Here, we highlight the most current progress on NLRP2 in inflammasome activation, effector function, and regulation of nuclear factor-κB. And we discuss functions of NLRP2 in inflammatory diseases, reproductive disorders, and the potential implication of NLRP2 in human diseases.
22 Jan 2023Reviewer(s) Assigned
03 May 2023Review(s) Completed, Editorial Evaluation Pending
09 May 2023Editorial Decision: Revise Minor
21 Jul 20231st Revision Received
24 Jul 2023Submission Checks Completed
24 Jul 2023Assigned to Editor
24 Jul 2023Review(s) Completed, Editorial Evaluation Pending
03 Aug 2023Reviewer(s) Assigned
08 Sep 2023Editorial Decision: Accept