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Pd-Catalyzed Asymmetric Allylic C-H Functionalization
  • Pu-Sheng Wang,
  • Liuzhu' Gong
Pu-Sheng Wang
University of Science and Technology of China
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Liuzhu' Gong
University of Science and Technology of China

Corresponding Author:[email protected]

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Abstract

Pd-catalyzed asymmetric allylic C−H functionalization has emerged as a powerful tool to access chiral, densely functionalized molecules from easily ac-cessible alkenes, enabling the increase of the step- or atom-economy by minimizing functional group manipulations for preparing allylating reagents. Due to the inadequacy of stereoselection strategies, the asymmetric allylic C-H functionalization is still in the early stage. In this essay, we will describe our journey to identification of asymmetric catalytic systems, mechanism of allylic C−H activation, control of stereo- and regioselectivity, and applica-tions in asymmetric synthesis.
21 Mar 20231st Revision Received
21 Mar 2023Submission Checks Completed
21 Mar 2023Assigned to Editor
21 Mar 2023Review(s) Completed, Editorial Evaluation Pending
21 Mar 2023Editorial Decision: Accept