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Femtosecond Optical Kerr Gate in Tissues
  • Henry J. Meyer,
  • Sandra Mamani,
  • Robert Alfano
Henry J. Meyer
The City College of New York

Corresponding Author:[email protected]

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Sandra Mamani
The City College of New York
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Robert Alfano
The City College of New York
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Abstract

The Optical Kerr Effect was investigated for the first time in biological tissues. This nonlinear optical effect was explored in both human brain and avian breast tissues using a time-resolved femtosecond pump-probe Optical Kerr Gate. The Optical Kerr Effect describes the nonlinear change in a material’s refractive index in response to an electric field. It is fundamental to spectral effects that are commonly used in biological science. The tested tissues produced a unique ultrafast (700-800 fs) doubled peaked Kerr signal, which is indicative of temporal interplay between the different components (electronic plasma, and molecular) that make up the Kerr index. Temporal properties varied between samples suggesting that this method could be used as a new diagnostic. Understanding this Kerr behavior can help improve current spectral diagnostic techniques, such as SRS, and potentially create a new Kerr based biopsy method for the detection of diseased tissues, such as cancer and Alzheimer’s.
25 Mar 2023Submitted to Journal of Biophotonics
28 Mar 2023Submission Checks Completed
28 Mar 2023Assigned to Editor
28 Mar 2023Review(s) Completed, Editorial Evaluation Pending
28 Mar 2023Reviewer(s) Assigned
02 May 2023Editorial Decision: Revise Major
21 May 20231st Revision Received
21 May 2023Submission Checks Completed
21 May 2023Assigned to Editor
21 May 2023Review(s) Completed, Editorial Evaluation Pending
21 May 2023Reviewer(s) Assigned
06 Jun 2023Editorial Decision: Revise Major
19 Jul 20232nd Revision Received
19 Jul 2023Submission Checks Completed
19 Jul 2023Assigned to Editor
19 Jul 2023Review(s) Completed, Editorial Evaluation Pending
19 Jul 2023Reviewer(s) Assigned
04 Aug 2023Editorial Decision: Accept