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Expression of SmATPDases in Schistosoma mansoni eggs favors IL-10 mediated modulation in infected individuals
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  • Pauline Martins Leite,
  • Thalisson Artur Ribeiro Gomides,
  • Márcio Luís Moreira de Souza,
  • Amanda Braga de Figueiredo,
  • Marlucy Rodrigues Lima,
  • Alda Maria Soares Silveira,
  • Girley Francisco Machado de Assis,
  • Lúcia Alves Oliveira Fraga,
  • Gabriela Silveira-Nunes,
  • Letícia Martucci,
  • Jennifer Delgado Garcia,
  • Luís Carlos Crocco Afonso,
  • Andrea Teixeira-Carvalho
Pauline Martins Leite
Universidade Federal de Juiz de Fora

Corresponding Author:[email protected]

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Thalisson Artur Ribeiro Gomides
Universidade Federal de Ouro Preto Departamento de Ciencias Biologicas
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Márcio Luís Moreira de Souza
Universidade Federal de Juiz de Fora
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Amanda Braga de Figueiredo
Universidade Federal de Ouro Preto Departamento de Ciencias Biologicas
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Marlucy Rodrigues Lima
Universidade Vale do Rio Doce
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Alda Maria Soares Silveira
Universidade Federal de Juiz de Fora
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Girley Francisco Machado de Assis
Universidade Federal de Juiz de Fora
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Lúcia Alves Oliveira Fraga
Universidade Federal de Juiz de Fora
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Gabriela Silveira-Nunes
Universidade Federal de Juiz de Fora
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Letícia Martucci
Universidade Federal de Juiz de Fora
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Jennifer Delgado Garcia
Universidade Federal de Juiz de Fora
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Luís Carlos Crocco Afonso
Universidade Federal de Ouro Preto Departamento de Ciencias Biologicas
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Andrea Teixeira-Carvalho
Fundacao Oswaldo Cruz Instituto Rene Rachou
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Abstract

Background and objectives: A role of IL-10 is down-regulating T cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in S. mansoni eggs. Patients/Methods: Fecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines was measured in supernatants of PBMC. The analysis was performed by the global median determination and set up high producers (HP) of cytokines. Results: Six individuals expressed SmATPDase1, six expressed SmATPDase2, and six expressed both enzymes. The group who expressed only SmATPDase1 showed a high frequency of IFN-γ, TNF, IL-4 HP, individuals who expressed only SmATPDase2 showed a high frequency of IFN-γ, IL-6, and IL-4 HP and individuals who expressed both enzymes showed a high frequency of IL-10 HP. In the group that showed expression both enzymes was observed lower indices the ratio between IFN-γ/IL-10. The positive correlation between infection intensity and IL-10 levels remained only in the positive SmATPDase group. The IL-10 is the only cytokine induced by the expression of both enzymes. Conclusions: The expression of both enzymes seems to be a factor that modulates the host immune response by inducing high IL-10 production.
18 Apr 2023Submitted to Parasite Immunology
20 Apr 2023Submission Checks Completed
20 Apr 2023Assigned to Editor
20 Apr 2023Review(s) Completed, Editorial Evaluation Pending
05 May 2023Reviewer(s) Assigned
19 Jun 2023Editorial Decision: Revise Minor
22 Jul 20231st Revision Received
22 Jul 2023Submission Checks Completed
22 Jul 2023Assigned to Editor
22 Jul 2023Review(s) Completed, Editorial Evaluation Pending
24 Jul 2023Reviewer(s) Assigned
16 Aug 2023Editorial Decision: Revise Minor
30 Aug 20232nd Revision Received
30 Aug 2023Review(s) Completed, Editorial Evaluation Pending
30 Aug 2023Submission Checks Completed
30 Aug 2023Assigned to Editor
01 Oct 2023Reviewer(s) Assigned
09 Oct 2023Editorial Decision: Accept