The potential of extracellular vesicle lipid profiling in Alzheimer's
disease.
- Huaqi Su,
- Colin Masters,
- Ashley Bush,
- Kevin Barnham,
- Gavin Reid,
- Laura Vella
Abstract
Over the past two decades, there has been increasing research into the
molecular composition and function of small extracellular vesicles in
the central nervous system. This is due in part to the recognition that
small extracellular vesicles likely contribute to the pathogenesis of
neurological diseases such as Alzheimer's disease, but also an
understanding that small extracellular vesicles are a source of
potential biomarkers. Small extracellular vesicles carry specific cargo
that reflects their biogenesis and cellular origins, including protein,
RNA and lipid. While the protein and RNA content of small extracellular
vesicles in the central nervous system diseases and have been studied
extensively, our understanding of the lipidome of small extracellular
vesicles in the central nervous system is still in its infancy. Lipids
play a significant role in maintaining central nervous system structure
and function, and the dysregulation of lipid metabolism is known to
occur in many neurological disorders, including Alzheimer's disease.
Here we review what is currently known about lipid dyshomeostasis in
Alzheimer's disease. We propose that small extracellular vesicle lipids
may provide insight into the pathophysiology and progression of
Alzheimer's disease and other neurological disorders, and, in the future
perhaps, aid in disease monitoring and detection.12 May 2023Submitted to PROTEOMICS 12 May 2023Submission Checks Completed
12 May 2023Assigned to Editor
12 May 2023Review(s) Completed, Editorial Evaluation Pending
12 May 2023Reviewer(s) Assigned
30 Jun 2023Editorial Decision: Revise Minor
08 Aug 2023Review(s) Completed, Editorial Evaluation Pending
08 Aug 20231st Revision Received
10 Aug 2023Reviewer(s) Assigned
14 Aug 2023Editorial Decision: Accept