Scoping review of relationship between alcohol, memory consolidation,
and ripple activity: recompilation of mean methodologies to analyze
ripples
Abstract
Alcohol abuse is not only responsible for 5.3% of the total deaths in
the world, but also has a substantial impact on neurological and memory
disabilities throughout the population. One extensively studied brain
area involved in cognitive functions is the hippocampus. Evidence in
several rodent models has shown that ethanol produces cognitive
impairment in hippocampal-dependent tasks and that the damage is varied
according to the stage of development at which the rodent was exposed to
ethanol and the dose. To the authors’ knowledge, there is a biomarker
for cognitive processes in the hippocampus that has not been evaluated
in association with memory impairment by alcohol administration. This
biomarker is called Sharp Wave Ripples which are synchronous neuronal
population events that are well known to be involved in memory
consolidation. Methodologies for facilitation or automatic
identification of ripples and their analysis have been reported for a
wider bandwidth than Sharp Wave Ripples. This review is focused on
communicating the state-of-the art about the relationship between
alcohol, memory consolidation and ripple activity as well as the use of
the main methodologies to identify SWRs automatically.