Objective : To evaluate the effects of Complete Decongestive Treatment (CDT) on both cancer-related fatigue and sleep quality using validated and reliable questionnaires in cancer patients is commendable. Material and Metods: 94 patients between the ages of 18 and 75 were included in the study. The demographic characteristics of the patients were recorded. The participants’ Stages of Lymphedema , Hirai Cancer Fatigue Scale (HCFS) score, Pittsburgh Sleep Quality Index (PSQI) Global score, lymphedema-specific quality of life questionnaire (LYMQOL- ARM) score, and Global health status were recorded before and after CDT. Results : The mean age of the patients was 58.49±10.96 years. Strong correlations were found between the severity of edema and global health status . There was a significant positive relationship among the HCFS score, PSQI Global score, LYMQOL- ARM score and CDT. After decongestive physiotherapy, majority of the lymphedema stages were downstaging .(P < 0.05), respectively. There was also a trend toward improvement in general well-being (P < 0.05). Conclusion : In our study, which is the first study to investigate the HCFS score in postmastectomy patients and relationship between PSQI Global score and CDT. The findings identify the risk factors that affect these outcomes in women with lymphedema can provide valuable insights for targeted interventions and improved patient care.