loading page

Measuring HE4 alongside CA125 for Ovarian Cancer Diagnosis: A pilot clinical study
  • +2
  • Michael Crawford S,
  • Colin Evans,
  • Alison Shaw,
  • Chloe Barr E,
  • Emma Crosbie
Michael Crawford S
Airedale NHS Foundation Trust

Corresponding Author:[email protected]

Author Profile
Colin Evans
Airedale NHS Foundation Trust
Author Profile
Alison Shaw
Airedale NHS Foundation Trust
Author Profile
Chloe Barr E
Manchester University NHS Foundation Trust
Author Profile
Emma Crosbie
Manchester University NHS Foundation Trust
Author Profile

Abstract

[The Instructions to Authors state no abstract is required for a Research Letter but the submission sysem demands one, so this text is included.] In order to assess whether measuring HE4 might add to the performance of CA125 in diagnosing ovarian cancer, we measured both markers in 33 individuals with elevated CA125. We found that HE4 elevated above 150 pmol/l was present in all 9 cases of ovarian cancer and in the single case of pancreatic cancer.  HE4 levels below 77pmol/l seen in 16 cases were associated with non-malignant gynaecological conditions and with there being no identified cause for elevated CA125. Two cases with HE4 between 77 and 149 pmol/l had no gynaecological conditions and 2 had no an identifiable cause.  Measuring both markers could lead to improved sensitivity and specificity of the initial diagnostic step.
24 Sep 2023Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
24 Sep 2023Submission Checks Completed
24 Sep 2023Assigned to Editor
24 Sep 2023Review(s) Completed, Editorial Evaluation Pending
25 Oct 2023Reviewer(s) Assigned
24 Jan 2024Editorial Decision: Revise Major
20 Mar 20241st Revision Received
24 Jun 2024Editorial Decision: Accept