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Pediatric Cutaneous Gamma-delta T-cell Neoplasm and Mimics: Not Always Aggressive
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  • Jinjun Cheng,
  • Keri Toner,
  • Kaiane Habeshian,
  • Michael Cardis,
  • Catherine Bollard,
  • Birte Wistinghausen,
  • Anna Kirkorian
Jinjun Cheng
Children's National Hospital

Corresponding Author:[email protected]

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Keri Toner
Children's National Hospital
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Kaiane Habeshian
Children's National Hospital
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Michael Cardis
MedStar Georgetown University Hospital
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Catherine Bollard
Children's National Hospital
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Birte Wistinghausen
Children's National Hospital
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Anna Kirkorian
Children's National Hospital
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Abstract

Pediatric cutaneous T-cell lymphoma with γδ immunophenotype is extremely rare. Only a few cases of γδ T-cell neoplasm have been reported in the literature and therefore little is known whether γδ T-cell neoplasms in children are distinct from their adult counterparts with respect to the clinicopathological presentation, behavior and prognosis. In this study, we demonstrate three unique cases with increased γδ T-cells in malignant and non-malignant skin conditions of children. All cases showed an indolent clinical course. Full integration of clinical presentation, morphology, immunophenotype, and genetics supports the correct diagnosis and guides the treatment.
27 Sep 2023Submission Checks Completed
27 Sep 2023Assigned to Editor
27 Sep 2023Submitted to Pediatric Blood & Cancer
27 Sep 2023Review(s) Completed, Editorial Evaluation Pending
28 Sep 2023Reviewer(s) Assigned
14 Oct 2023Editorial Decision: Revise Major
31 Oct 20231st Revision Received
31 Oct 2023Submission Checks Completed
31 Oct 2023Assigned to Editor
08 Nov 2023Review(s) Completed, Editorial Evaluation Pending
08 Nov 2023Reviewer(s) Assigned