Pediatric Cutaneous Gamma-delta T-cell Neoplasm and Mimics: Not Always
Aggressive
Abstract
Pediatric cutaneous T-cell lymphoma with γδ immunophenotype is extremely
rare. Only a few cases of γδ T-cell neoplasm have been reported in the
literature and therefore little is known whether γδ T-cell neoplasms in
children are distinct from their adult counterparts with respect to the
clinicopathological presentation, behavior and prognosis. In this study,
we demonstrate three unique cases with increased γδ T-cells in malignant
and non-malignant skin conditions of children. All cases showed an
indolent clinical course. Full integration of clinical presentation,
morphology, immunophenotype, and genetics supports the correct diagnosis
and guides the treatment.