Purpose This study aimed to explore the correlation between morphological parameters and dosimetric parameters of the heart and spinal cord in advanced-stage esophagus cancer (EPC) to provide a reference for clinical treatment. Methods A total of 105 patients with middle- and advanced-stage EPC, who received treatment in our hospital from 2019 to 2021, were included. The morphological parameters were calculated by imaging. Intensity-modulated radiation therapy plan was executed at Raystation4.7. The prescription dose of PTV-G and PTV-C was set as 60Gy/30F and 54Gy/30F, respectively. The linear regression model was used to analyze the correlation between morphologic parameters of EPC and dosimetric parameters of the heart and spinal cord. Results In 105 cases, the total lung length was correlated with the spinal cord D2. The heart Dmean and heart V40 was correlated with PTV-G volume, PTV-G length; In middle- and upper-segment EPC cases, only the total lung volume was correlated with the spinal cord Dmean, spinal cord D2, heart Dmean, and heart V40; In middle-stage EPC cases, the heart Dmean was correlated with the PTV-G volume, PTV-G length. the total lung length was correlated with the spinal cord D2; In middle- and lower-segment EPC, only the PTV-G volume and PTV-G length were correlated with the heart Dmean. All the aforementioned values were statistically significant. Conclusions Combined with the non-segmented tumor and different locations, the organ at risk dose was comprehensively considered.