loading page

Asymmetric Hydrogenation of Phenanthridines with Chiral Boranes
  • Guangyu Cui,
  • Xiangqing Feng,
  • Haifeng Du
Guangyu Cui
Institute of Chemistry Chinese Academy of Sciences
Author Profile
Xiangqing Feng
Institute of Chemistry Chinese Academy of Sciences
Author Profile
Haifeng Du
Institute of Chemistry Chinese Academy of Sciences

Corresponding Author:[email protected]

Author Profile

Abstract

The asymmetric hydrogenation of N-heteroarenes provides an efficient method for the synthesis of optically active cyclic secondary amines. In this paper, we described an asymmetric hydrogenation of phenanthridines using a chiral mono-alkene-derived borane. A variety of dihydrophenanthridines were furnished in high yields with up to 93% ee. The current catalytic system was very sensitive for the steric hindrance of phenanthridines. Bulky substituents at one phenyl group of phenanthridines were required to obtain the high enantioselectivity. But large substituents adjacent to the C=N bonds would diminish the reactivity sharply.
13 Nov 20231st Revision Received
14 Nov 2023Review(s) Completed, Editorial Evaluation Pending
14 Nov 2023Submission Checks Completed
14 Nov 2023Assigned to Editor
16 Nov 2023Editorial Decision: Accept