High Mean Platelet Volume and MPV/Platelet Ratio Predict Mortality for
COVID-19 Patients in Intensive Care Unit
Abstract
Background:Mean platelet volum to platelet count (MPV/Plt) ratio (MPR)
is a new predictor of mortality in critical patients with COVID-19
infection in intensive care unit (ICU). Objective:To retrospectively
examine the laboratory predictors of mortality among COVID-19 patients.
Materials and Methods:A total of 106 patients with COVID-19 in ICU were
enrolled in the study.The medical records of the patients and the
electronic patient monitoring system were retrospectively analyzed.
Results:The Interleukin-6, C-reactive protein (CRP), procalcitonin,
leukocyte count, neutrophil count, neutrophil %, neutrophil
count/lymphocyte count (NLR) and neutrophil count/albumin (NAR) ratio
was significantly higher among nonsurvivors (p=0.0001, p=0.004, p=0.003,
p=0.049, p=0.007, p=0.009, p=0.007 and p=0.0001; respectively).While the
survivors had lower platelet distribution width, red blood cell
distribution width, MPV and MPR (p=0.016, p=0.03, p=0.005 and p=0.049;
respectively), hemoglobin, Plt, mean corpuscular hemoglobin
concentration, lymphocyte % ve monocyte % were higher (p=0.022,
p=0.033, p=0.042, p=0.008 and p=0.04; respectively). In the logistic
regression analysis, five features, including high levels of CRP,
procalsitonin, pro-BNP, MPR, and low level of plt were shown as
mortality predictors for COVID-19 patients in ICU (p=0.045, p=0.025,
p=0.017, p=0.027 and p=0.041; respectively). Conclusion:Mean platelet
volum to platelet count ratio, NLR, NAR predict mortality in critical
cases of COVID-19 which will contribute to early prediction, accurate
diagnosis, and treatment to improve the prognosis of patients. Keywords:
COVID-19, mortality, MPV, MPV/platelet ratio, NLR, platelet