A systematic review of molecular mechanism and therapeutic effect of
Cannabidiol (CBD)
Abstract
Cannabidiol (CBD) is an abundant non-psychoactive phytocannabinoid in
Cannabis extracts. Mechanic studies have indicated that CBD has high
affinity on a series of receptors, including type 1 cannabinoid receptor
(CB1), type 2 cannabinoid receptor (CB2), GPR55, transient receptor
potential vanilloid (TRPV), peroxisome proliferator-activated receptor
gamma (PPARγ). By modulating the activities of these receptor, CBD
exhibits multiple therapeutic effects, including neuroprotective,
antiepileptic, anxiolytic, antipsychotic, anti-inflammatory, analgesic
and anti-cancer properties. Recently, according to some initial studies,
CBD’s anti-inflammatory properties could be applied for treat or prevent
COVID-19. CBD has gained increased attention in recent years because of
its great potential to treat various human diseases. This review
provides a current overview of CBD’s applications in human diseases,
from mechanism of action to clinical trials.