Comparing the severity of Outcomes of SARS-CoV-2 between RT-PCR-positive
and RT-PCR-negative Individuals in Iran Comparing the severity of
Outcomes of SARS-CoV-2 between RT-PCR-positive and RT-PCR-negative
Individuals in Iran
Abstract
The aim of this study was to compare the outcomes of SARS-CoV-2
RT-PCR-positive and RT-PCR negative Patients in Iran. This cohort study
performed on 81393 patients with COVID-19 in six provinces of Iran
during 2020. The studied variables include demographic and clinical. To
examine the associations between RT-PCR test and death or ICU admission
as dependent variable the multiple Bayesian logistic regression model
was used by R software. 81393 individual (44.9 % female) with a mean
age of 52.98 ± 20.8 years were included to the analysis. At all, 25434
tests (31.2 %) were positive RT-PCR, including 10772 men (44.9%) and
14662 women (55.1%). The multiple Bayesian logistic regression model
showed a significant positive association between RT-PCR test results
and COVID-19 mortality rate (OR: 1.46; 95% Crl: 1.29- 1.64). Also,
males, older age, individual with chronic disease have higher risk of
COVID-19 death, however, negative association observed between history
of contact and COVID-19 death. We observed a significant inverse
association between RT-PCR test results and ICU admission, while, the
risk of ICU admission increased significantly by 1.2 times (95% Crl for
odds ratio: 1.09, 1.34) among patients with negative RT-PCR test
compared to positive RT-PCR test. People with positive RT-PCR test, male
gender, older age, having a history of underlying disease have a higher
risk of death and hospitalization in the ICU. Therefore, paying
attention to these factors will be effective in reducing the risk of
death and hospitalization in ICU.