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Microhomology-mediated repair machinery and its relationship with HPV-mediated oncogenesis
  • Gabe Starrett,
  • Subhajit Chatterjee
Gabe Starrett
National Cancer Institute Center for Cancer Research

Corresponding Author:[email protected]

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Subhajit Chatterjee
National Cancer Institute Center for Cancer Research
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Abstract

Human Papillomaviruses (HPV) are a diverse family of non-enveloped dsDNA viruses that infect the skin and mucosal epithelia. Persistent HPV infections can lead to cancer frequently involving integration of the virus into the host genome, leading to sustained oncogene expression and loss of capsid and genome maintenance proteins. Microhomology-mediated double-strand break repair, a DNA double-stranded breaks repair pathway present in many organisms, was initially thought to be a backup but it’s now seen as vital, especially in homologous recombination-deficient contexts. Increasing evidence has identified microhomology (MH) near HPV integration junctions, suggesting MH-mediated repair pathways drive integration. In this comprehensive review, we present a detailed summary of both the mechanisms underlying MH-mediated repair and the evidence for its involvement in HPV integration in cancer. Lastly, we highlight the involvement of these processes in the integration of other DNA viruses and the broader implications on virus lifecycles and host innate immune response.
26 Jan 2024Review(s) Completed, Editorial Evaluation Pending
29 Jan 2024Editorial Decision: Revise Minor
20 Apr 20241st Revision Received
21 Apr 2024Submission Checks Completed
21 Apr 2024Assigned to Editor
21 Apr 2024Review(s) Completed, Editorial Evaluation Pending
22 Apr 2024Reviewer(s) Assigned