Although there have been numerous recent advancements in medicine, the prognosis for glioblastoma multiforme (GBM), is still poor. The blood-brain barrier (BBB) places restrictions on GBM treatment. To enhance therapeutic effects, medicines must aggregate at the tumor site. In this review, peptide-modified nanoplatforms were discussed as not only do they cross the BBB but some like RVG29 could also accumulate specifically in cerebral glioma tissue. The use of magnetic nanoparticles in magnetic hyperthermia which heats the tumor tissues under alternating magnetic fields was discussed. Its use alone and in combination with other adjuvant therapies was analyzed. Using modified Iron oxide nanoparticles, magnetic hyperthermia can also be used with T ₁/T ₂ MRI. Additionally, the use of sonodynamic therapy as a novel and efficient non-invasive way of treating cancer cells was examined. Moreover, research on photo penetration via the brain’s tissues was discussed. In humans’ head (scalp plus skull), the red/NIR (630-810 nm) light penetration ranged from 0.2-10%. In addition, the superadditive treatment efficacy of using Fe ₃O ₄ when combined with photodynamic and photothermal therapy was discussed, it demonstrated superior efficacy in eliminating glioma as compared to employing each treatment modality alone or in combination. Finally, according to the superadditive (i.e. ”1+1>2”) effect, and the studies reviewed. It is believed combining rather safe therapies, such as MHCT, PTT, and PDT with appropriate nanoplatforms that are coated with BBB and GBM cells targeting ligands, Could result in enhanced GBM therapy and MRI monitoring.