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The Ghost of Parvovirus Past: Idiopathic Pure Red Cell Aplasia Responding to IVIG Following Resolved Perinatal Parvovirus B19 Infection
  • +5
  • Nathan Gray,
  • Kacie Sims,
  • Sara Lewis,
  • Shaohua Lei,
  • Nidhi Bhatt,
  • Gabriela Gheorghe,
  • Clifford Takemoto,
  • Marcin Wlodarski
Nathan Gray
St Jude Children's Research Hospital
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Kacie Sims
Franciscan Missionaries of Our Lady Health System
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Sara Lewis
St Jude Children's Research Hospital
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Shaohua Lei
St Jude Children's Research Hospital
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Nidhi Bhatt
St Jude Children's Research Hospital
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Gabriela Gheorghe
St Jude Children's Research Hospital
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Clifford Takemoto
St Jude Children's Research Hospital
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Marcin Wlodarski
St Jude Children's Research Hospital

Corresponding Author:[email protected]

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Abstract

Pure red cell aplasia (PRCA) is characterized by isolated anemia and a marked reduction or absence of erythroid precursors in the bone marrow. Depending on the underlying etiology, treatment may include immunomodulation or cytotoxic agents, chronic red blood cell transfusions, or hematopoietic stem cell transplantation. Parvovirus B19 infection is a well-recognized cause of transient PRCA, typically resolving with viral clearance. We report an unusual late relapse of PRCA occurring years after parvovirus B19 eradication, unresponsive to steroids and mycophenolate mofetil. Remarkably, prolonged treatment with intravenous immune globulin (IVIG) resulted in complete remission, highlighting its therapeutic utility for idiopathic PRCA.
Submitted to Pediatric Blood & Cancer
21 Apr 2024Review(s) Completed, Editorial Evaluation Pending
30 Apr 2024Editorial Decision: Revise Major
25 Jul 2024Submission Checks Completed
25 Jul 20241st Revision Received
25 Jul 2024Assigned to Editor
26 Jul 2024Review(s) Completed, Editorial Evaluation Pending
26 Jul 2024Editorial Decision: Accept