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Diagnosis and Management of Food Allergy Induced Constipation in young Children -- An EAACI Position Paper
  • +11
  • Rosan Meyer,
  • Yvan Vandenplas,
  • Adriana Chebar Lozinsky,
  • Mario Vieira,
  • Roberto Berni Canani,
  • George Du Toit,
  • Christophe Dupont,
  • Mattia Giovannini,
  • Pinar Uysal,
  • Ozlem Cavkaytar,
  • Rebecca Knibb,
  • David Fleischer,
  • Anna Nowak-wegrzyn,
  • Carina Venter
Rosan Meyer
University of Winchester

Corresponding Author:[email protected]

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Yvan Vandenplas
Vrije Universiteit Brussel - Brussels Health Campus
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Adriana Chebar Lozinsky
Murdoch Children's Research Institute
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Mario Vieira
Hospital Pequeno Principe
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Roberto Berni Canani
Universita degli Studi di Napoli Federico II Dipartimento di Medicina Clinica e Chirurgia
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George Du Toit
Evelina London Children's Hospital Paediatrics
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Christophe Dupont
Hopital universitaire Necker-Enfants malades Service de Pediatrie generale
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Mattia Giovannini
Azienda Ospedaliero Universitaria Meyer Pediatria medica
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Pinar Uysal
Adnan Menderes Universitesi Tip Fakultesi
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Ozlem Cavkaytar
Istanbul Medeniyet Universitesi Tip Fakultesi
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Rebecca Knibb
Aston University School of Psychology
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David Fleischer
University of Colorado System
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Anna Nowak-wegrzyn
Icahn School of Medicine at Mount Sinai Department of Pediatrics
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Carina Venter
University of Colorado Anschutz Medical Campus Department of Medicine
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Abstract

The recognition of constipation as a possible non-Immunoglobulin E (IgE) mediated allergic condition is challenging because functional constipation (unrelated to food allergies) is a common health problem with a reported worldwide prevalence rate of up to 32.2% in children. However, many studies in children report challenge proven cow’s milk allergy and constipation as a primary symptom, have found that between 28-78% of children improve on a cow’s milk elimination diet. Due to the paucity of data and a focus on IgE mediated allergy, not all food allergy guidelines list constipation as a symptom of food allergy. Yet, it is included in all cow’s milk allergy guidelines available in English language. The Exploring Non- IgE Mediated Allergy(ENIGMA) Task Force (TF) of the European Academy for Allergy and Clinical Immunology (EAACI) considers in this paper constipation in the context of failure of standard treatment and discuss the role of food allergens as culprit in constipation in children. This position paper has used the Delphi approach in reaching consensus on both diagnosis and management, as currently published data is insufficient to support a systematic review.
05 Apr 2024Submitted to Pediatric Allergy and Immunology
15 Apr 2024Reviewer(s) Assigned
08 May 2024Review(s) Completed, Editorial Evaluation Pending
10 May 2024Editorial Decision: Accept