High-grade tumor budding influences prognosis of I-II stage cervical
cancer: a systematic review and meta-analysis
Abstract
Objective: The aim of this study is to investigate the prognostic
correlation between tumor budding and stage I-II cervical cancer, with
the goal of providing guidance for postoperative diagnosis and treatment
strategies for patients.Methods: A comprehensive search was conducted
across 12 databases including Pubmed, Cochrane, Embase, Scopus, OVID,
Web of Science, EBSCohost, CNKI, Wan-Fang, VIP, Dui-Xiu and CBM to
identify relevant literature on the association between tumor budding
and prognosis or clinicopathological features of cervical cancer.The
quality of included studies was assessed using the Newcastle-Ottawa
scale. Statistical analysis was performed using Review Manager.Results:
Our findings demonstrate that high-grade tumor budding in stage I-II
cervical cancer is associated with significantly poorer overall survival
(P<0.0001) and disease-free survival (P<0.0001).
Subgroup analyses revealed that irrespective of sample size and
histological type, the overall survival in the high-grade tumor budding
group is markedly lower than that in the low-grade tumor budding group;
similarly regardless of stage inclusion criteria, budding type, field
boundary value or sample size,the disease-free survival in the
high-grade tumor budding group is significantly lower than that in the
low-grade tumor budding group.Furthermore,high grade tumor budding is
correlated with several adverse pathological features.Conclusion: In
light of these results,it can be concluded that tumor budding serves as
an unfavorable prognostic factor for stage I-II cervical cancer,and may
inform I-II stage postoperative treatment planning for such patients.