Mucosal associated invariant T cells (MAIT cells) are a group of evolutionarily conserved and unconventional innate-like T cell subsets. Since first defined in 2003, it has been found to be involved in physiological and pathological process. The study is aimed to explore the research content, present hotspots and future trends of MAIT cells through bibliometric approach. The publication was searched using Web of Science Core Collection database (WoSCC). The bibliometrix package in R was used for data extraction and quantitative analysis of bibliometrics and scientometrics. A cloud plot was generated to display the hotspots of WoSCC keywords in MAIT cell researches. Thematic analysis and trend topics map were conducted to appraise the maturity and development trend of topics in MAIT cell studies. The collaboration network, including author collaboration and affiliation collaboration, were visualized by using VOSviewer. A total of 1041 related publications obtained from WoSCC were analyzed. It is found that nearly 10 years researches on MAIT cells surging with the US being the major producer. The groups of James McCluskey and Jamie Rossjohn contributed most to the research of MAIT cells. “Frontiers in Immunology” and “Journal of Immunology” were the most prolific. Activation and function are the hotspots of the researches of MAIT cells. Applying advanced sequencing technology to explore the interaction of MAIT cells with microbiota in diseases may be the research trend.The bibliometric analysis provides novel and useful data for the MAIT research scientific community, which was conducive to elucidating MAIT cells more effectively and intuitively.