Cognitive-behavioral therapy ameliorates subjective tinnitus by
ameliorating anxiety and depressive states, two-sample Mendelian
randomization and meta-analysis
Abstract
Abstract Introduction: Subjective tinnitus is identified as a
hallucinatory perception occurring in individuals. Our aim was to
explore the underlying mechanisms of cognitive behavioural therapy in
the treatment of tinnitus. Material and methods: We performed a
meta-analysis of observational studies identified from 4 databases to
evaluate the associations of cognitive behaviorial therapy and
subjective tinnitus from 1990 to 2023. We conducted MR analyses to
strengthen the causal inference in these associations. Independent
single-nucleotide polymorphisms without linkage disequilibrium (r2
< 0.001) that were strongly associated (P < 5 × 10
-8) with anxiety and depressive states on GWAS. Data
on Tinnitus were obtained from a GWAS data for tinnitus was acquired
from FinnGen research. Results: Mendelian randomization showed that
there was a clear causal relationship between anxiety and depression and
tinnitus. The results of the meta-analysis suggest that cognitive
behavioral therapy has a positive effect on improving the psychoacoustic
symptoms of tinnitus. Conclusion: Cognitive-behavioral therapy can have
a positive impact on the psychoacoustic level of tinnitus by improving
the patient’s anxiety and depression state.